GLP-1 receptor agonist

Liraglutide

Sold as Saxenda, Victozaonce daily, subcutaneous injection.

Mean weight change · SCALE

-8%

Placebo arm

-2.6%

Duration

56 wk

What the number means

Mean change in body weight at 56 weeks on 3.0 mg daily, in adults with overweight or obesity.

Trial averages are not a forecast for any individual. Response varies widely, the trial population was screened and supported in ways a subscription is not, and the figure describes people who stayed on the medication for the full period.

Worth knowing

  • A daily injection rather than weekly, which is the main reason people leave it.
  • Now available as a generic in several markets, which makes it by far the cheapest way into this class.
  • Smaller average effect, but a longer real-world safety record than the newer agents.

Approved for

Type 2 diabetes (Victoza) and chronic weight management (Saxenda), with a paediatric indication from age 12 for Saxenda.